From: Jocelyn Leu josniko@hotmail.com
Subject:[NMusers] Emax modeling question
Date: 11/18/2003 9:38 AM
Hi all,
I am trying to fit data to the general Emax model. We have tried
2 subjects and the control stream works ($PRED). However, when
we use the entire data set, there are error messages. From what
we can see, NONMEM is having problems with the data file. I have
multiple values of "0" for concentration and different values for
effect. Has anyone experienced this or have a solution? I'd like
delete as little data as possible.
Thanks!
Emax modeling question
From: "Bhattaram, Atul" BhattaramA@cder.fda.gov
Subject: RE: [NMusers] Emax modeling question
Date: 11/18/2003 10:14 AM
Hello Leu
When you say "0" do you mean concentrations below "LOQ" or pre-dose? How
different is the overall data from the 2 subjects? You dont have to delete
any data.
Venkatesh Atul Bhattaram
CDER, FDA.
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