Dear all,
I am trying to develop a model for a drug that was administered in multiple
doses to outpatient paediatric patients. Blood samples were collected after the
last dose and most of the patients have a concentration at 0hr time point. The
drug follows a one compartment model and has a short halflife. I am not sure
how to incorporate the previous dose to reflect the 0hr concentration. I would
highly appreciate if you could help me in setting up the data file .
Data of a patient after 9 doses of the drug at 6 hourly interval.
ID TIME DV AMT DOSE MDV ADDL II
1 0 0 179.4 179.4 1 9 6
1 0 0.5 0 179.4 0 0 0
1 0.35 10.1 0 179.4 0 0 0
1 0.68 12.1 0 179.4 0 0 0
1 1 12.2 0 179.4 0 0 0
1 1.5 8.9 0 179.4 0 0 0
1 2 7.2 0 179.4 0 0 0
1 4 3.6 0 179.4 0 0 0
1 6 2.1 0 179.4 0 0 0
1 8 2.2 0 179.4 0 0 0
Thanks
Ganesh Mugundu
Data File
I suggest that you look at NONMEM Users Guide VIII, EXOGENOUS
SUPPLEMENTATION EXAMPLE
>From the example:
A fragment of the data follows. Record 1 specifies the SS infusion
for the pre-existing drug, which ends at time 0. Record 2 gives the
baseline observation.
Note also the use of R1 in the $PK block.
On Wed, 26 Sep 2007 16:14:36 -0400 (EDT), "Ganesh Mugundu"
<[EMAIL PROTECTED]> said:
> Dear all,
>
> I am trying to develop a model for a drug that was administered in
> multiple doses to outpatient paediatric patients. Blood samples were
> collected after the last dose and most of the patients have a
> concentration at 0hr time point. The drug follows a one compartment model
> and has a short halflife. I am not sure how to incorporate the previous
> dose to reflect the 0hr concentration. I would highly appreciate if you
> could help me in setting up the data file .
>
> Data of a patient after 9 doses of the drug at 6 hourly interval.
>
> ID TIME DV AMT DOSE MDV ADDL II
> 1 0 0 179.4 179.4 1 9 6
> 1 0 0.5 0 179.4 0 0 0
> 1 0.35 10.1 0 179.4 0 0 0
> 1 0.68 12.1 0 179.4 0 0 0
> 1 1 12.2 0 179.4 0 0 0
> 1 1.5 8.9 0 179.4 0 0 0
> 1 2 7.2 0 179.4 0 0 0
> 1 4 3.6 0 179.4 0 0 0
> 1 6 2.1 0 179.4 0 0 0
> 1 8 2.2 0 179.4 0 0 0
>
> Thanks
> Ganesh Mugundu
>
--
Alison Boeckmann
[EMAIL PROTECTED]
If you do not have times of the previous doses, assume steady state:
> ID TIME DV AMT DOSE MDV SS II
> 1 0 0 179.4 179.4 1 1 6
> 1 0 0.5 0 179.4 0 0 0
> 1 0.35 10.1 0 179.4 0 0 0
> 1 0.68 12.1 0 179.4 0 0 0
> 1 1 12.2 0 179.4 0 0 0
> 1 1.5 8.9 0 179.4 0 0 0
> 1 2 7.2 0 179.4 0 0 0
> 1 4 3.6 0 179.4 0 0 0
> 1 6 2.1 0 179.4 0 0 0
> 1 8 2.2 0 179.4 0 0 0
If you know the time of the previous dose, assume that dose at steady state, set time zero at the time of that dose, and add the last dose:
> ID TIME DV AMT DOSE MDV SS II
> 1 0 0 179.4 179.4 1 1 6
> 1 6 0 179.4 179.4 1 0 0
> 1 6 0.5 0 179.4 0 0 0
> 1 6.35 10.1 0 179.4 0 0 0
> 1 6.68 12.1 0 179.4 0 0 0
> 1 7 12.2 0 179.4 0 0 0
> 1 7.5 8.9 0 179.4 0 0 0
> 1 8 7.2 0 179.4 0 0 0
> 1 10 3.6 0 179.4 0 0 0
> 1 12 2.1 0 179.4 0 0 0
> 1 14 2.2 0 179.4 0 0 0
If the interval between two last doses is exactly II=6, then both variants are equally good; otherwise, the second one could be a little better
Leonid
-------------------
Leonid Gibiansky
President
QuantPharm LLC
www.quantpharm.com
Ganesh Mugundu wrote:
> Dear all,
>
> I am trying to develop a model for a drug that was administered in multiple
> doses to outpatient paediatric patients. Blood samples were collected after the
> last dose and most of the patients have a concentration at 0hr time point. The
> drug follows a one compartment model and has a short halflife. I am not sure
> how to incorporate the previous dose to reflect the 0hr concentration. I would
> highly appreciate if you could help me in setting up the data file .
>
> Data of a patient after 9 doses of the drug at 6 hourly interval.
>
> ID TIME DV AMT DOSE MDV ADDL II
> 1 0 0 179.4 179.4 1 9 6
> 1 0 0.5 0 179.4 0 0 0
> 1 0.35 10.1 0 179.4 0 0 0
> 1 0.68 12.1 0 179.4 0 0 0
> 1 1 12.2 0 179.4 0 0 0
> 1 1.5 8.9 0 179.4 0 0 0
> 1 2 7.2 0 179.4 0 0 0
> 1 4 3.6 0 179.4 0 0 0
> 1 6 2.1 0 179.4 0 0 0
> 1 8 2.2 0 179.4 0 0 0
>
> Thanks
> Ganesh Mugundu