*Position Title: Associate Director Pharmacometrics*
*Job Description:*
The digital revolution is changing everything, especially in
pharmaceuticals where we are collecting more data in our clinical trials
than ever before. The question is, what do we do with it? At Novartis, we
have over 20 years of untapped data waiting to be explored – thereby
unlocking the secrets of the next breakthrough in innovative medicines for
patients in need.
Come to an industry leader where you will have the opportunity to provide
quantitative support for early clinical drug development. The successful
candidate will be the lead for Pharmacometrics in the Neuroscience disease
area. S/he should have diverse modeling experience in drug development
within pharma/biotech and a strong knowledge of best regulatory practices,
pharmacometric data structures and approaches. This role requires agility
in being able to handle both hands-on modeling and strategic leadership for
a dynamic project portfolio and strong written and oral communication
skills. It is very essential that the successful candidate can work
collaboratively across global teams. This is not a people management
position but is a key and visible leadership role in early development.
*Accountabilities:*
· Work within a matrixed organization to coordinate and maintain
strategic support for the portfolio of projects entering clinical
development up to transition to Phase 2
· Develop and communicate the quantitative rationale for dose and
schedule selection, safety margin, dose adjustment and patient
selection/stratification
· Scope the key questions and assess the required time and effort
needed and the appropriate Pharmacometric resources
· Work closely with partners in the disease area from other
functions such as Biostatistics, Clinical pharmacology, Pre-clinical
modeling, Translational Medicine, Safety, Biomarkers and Research
· Represent Pharmacometrics and effectively communicate
pharmacometric input on disease area decision boards
· Work with other modelers providing support within the disease
area to ensure that the support to decision making is appropriate and timely
*EEO Statement*
*The Novartis Group of Companies are Equal Opportunity Employers and take
pride in maintaining a diverse environment. We do not discriminate in
recruitment, hiring, training, promotion or any other employment practices
for reasons of race, color, religion, gender, national origin, age, sexual
orientation, marital or veteran status, disability, or any other legally
protected status.*
*Minimum requirements*
Position will be filled at level commensurate with experience.
*Education: *PhD in Pharmaceutical sciences, Clinical pharmacology,
mathematics, statistics, engineering or other quantitative discipline
preferred
*Experience:*
· Strong background in modeling and core expertise in NLME methods
and its application in Dose-exposure response analysis, population PK/PD
modeling, disease progression modeling and clinical trial simulation
· Good knowledge of statistics and data analysis; experience in
machine learning techniques is an asset
· Diverse experience in pharma industry on incorporation of M&S
strategies into drug development plans
· Ability to develop and deliver clear and concise presentations
for both internal and external meetings
· Experienced users of R and Monolix (or NONMEM). If NONMEM then
willingness to learn Monolix
· Experience in Neuroscience is an asset
*Why consider Novartis? *
927 million. That’s how many lives our products touched in 2017. And while
we’re proud of that fact, in this world of digital and technological
transformation, we must also ask ourselves this: how can we continue to
improve and extend even more people’s lives?
We believe the answers are found when curious, courageous and collaborative
people like you are brought together in an inspiring environment. Where
you’re given opportunities to explore the power of digital and data. Where
you’re empowered to risk failure by taking smart risks, and where you’re
surrounded by people who share your determination to tackle the world’s
toughest medical challenges.
We are Novartis. Join us and help us reimagine medicine.
Please go to the following link for more information and to apply
https://www.novartis.com/careers/career-search/job-details/258709BR
--
*Mirjam N. Trame, Pharm.D., Ph.D.*
Associate Director Pharmacometrics,
Precision Medicine
Phone: +1 (617) 252 2004 (ext 42004)
Cell: +1 (617) 599 8386
[email protected]
*Novartis Pharma AG*
45 Sidney Street
Cambridge, MA 02139
USA