Associate Director Position in Pharmacometrics at Novartis

*Position Title: Associate Director Pharmacometrics* *Job Description:* The digital revolution is changing everything, especially in pharmaceuticals where we are collecting more data in our clinical trials than ever before. The question is, what do we do with it? At Novartis, we have over 20 years of untapped data waiting to be explored – thereby unlocking the secrets of the next breakthrough in innovative medicines for patients in need. Come to an industry leader where you will have the opportunity to provide quantitative support for early clinical drug development. The successful candidate will be the lead for Pharmacometrics in the Neuroscience disease area. S/he should have diverse modeling experience in drug development within pharma/biotech and a strong knowledge of best regulatory practices, pharmacometric data structures and approaches. This role requires agility in being able to handle both hands-on modeling and strategic leadership for a dynamic project portfolio and strong written and oral communication skills. It is very essential that the successful candidate can work collaboratively across global teams. This is not a people management position but is a key and visible leadership role in early development. *Accountabilities:* · Work within a matrixed organization to coordinate and maintain strategic support for the portfolio of projects entering clinical development up to transition to Phase 2 · Develop and communicate the quantitative rationale for dose and schedule selection, safety margin, dose adjustment and patient selection/stratification · Scope the key questions and assess the required time and effort needed and the appropriate Pharmacometric resources · Work closely with partners in the disease area from other functions such as Biostatistics, Clinical pharmacology, Pre-clinical modeling, Translational Medicine, Safety, Biomarkers and Research · Represent Pharmacometrics and effectively communicate pharmacometric input on disease area decision boards · Work with other modelers providing support within the disease area to ensure that the support to decision making is appropriate and timely *EEO Statement* *The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.* *Minimum requirements* Position will be filled at level commensurate with experience. *Education: *PhD in Pharmaceutical sciences, Clinical pharmacology, mathematics, statistics, engineering or other quantitative discipline preferred *Experience:* · Strong background in modeling and core expertise in NLME methods and its application in Dose-exposure response analysis, population PK/PD modeling, disease progression modeling and clinical trial simulation · Good knowledge of statistics and data analysis; experience in machine learning techniques is an asset · Diverse experience in pharma industry on incorporation of M&S strategies into drug development plans · Ability to develop and deliver clear and concise presentations for both internal and external meetings · Experienced users of R and Monolix (or NONMEM). If NONMEM then willingness to learn Monolix · Experience in Neuroscience is an asset *Why consider Novartis? * 927 million. That’s how many lives our products touched in 2017. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives? We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges. We are Novartis. Join us and help us reimagine medicine. Please go to the following link for more information and to apply https://www.novartis.com/careers/career-search/job-details/258709BR -- *Mirjam N. Trame, Pharm.D., Ph.D.* Associate Director Pharmacometrics, Precision Medicine Phone: +1 (617) 252 2004 (ext 42004) Cell: +1 (617) 599 8386 [email protected] *Novartis Pharma AG* 45 Sidney Street Cambridge, MA 02139 USA