alt on Q in 2 compartment model

2 messages 2 people Latest: Oct 17, 2011

alt on Q in 2 compartment model

From: 风都扁扁 Date: October 17, 2011 technical
Hey all, I find ALT as a covariate on intercompartment clearance - Q in a two compartment model, the p-value = 0.0047. Is it reasonable? Thanks in advance! kevin

Re: alt on Q in 2 compartment model

From: Nick Holford Date: October 17, 2011 technical
Kevin, P values are irrelevant to deciding if something is reasonable. Reasonable means you can propose a biological reason for ALT providing an explanation for between subject differences in Q. Can you propose any reason? Does it make sense given the size and direction of the possible assocation of ALT with Q? Nick
Quoted reply history
On 17/10/2011 8:01 p.m., .风都扁扁 wrote: > Hey all, > > I find ALT as a covariate on intercompartment clearance - Q in a two compartment model, the p-value = 0.0047. > > Is it reasonable? > > Thanks in advance! > > kevin -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology& Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected] http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford