allometric scaling for renal elimination drug

2 messages 2 people Latest: Aug 03, 2011

allometric scaling for renal elimination drug

From: Chao Zhang Date: August 03, 2011 technical
Dear NMuser, I have a question about allometric scaling. Can allometric scaling be used to a renal elimination drug? Thanks. Chao Zhang Division of Clinical Pharmacology Department of Medicine University of Cape Town K45, Old Main Building Groote Schuur Hospital Observatory 7925 Cape Town South Africa Tel : +27 021 4047719 Fax: +27 021 4481989

Re: allometric scaling for renal elimination drug

From: Nick Holford Date: August 03, 2011 technical
Chao, The answer to your simple question is "yes". This paper describes the use of allometric scaling for GFR -- the prototype for all renal elimination processes. Rhodin MM, Anderson BJ, Peters AM, Coulthard MG, Wilkins B, Cole M, et al. Human renal function maturation: a quantitative description using weight and postmenstrual age. Pediatr Nephrol. 2009;24(1):67-76. Best wishes, Nick
Quoted reply history
On 4/08/2011 2:46 a.m., CHAO ZHANG wrote: > Dear NMuser, > > I have a question about allometric scaling. Can allometric scaling be used to a renal elimination drug? > > Thanks. > Chao Zhang > Division of Clinical Pharmacology > Department of Medicine > University of Cape Town > K45, Old Main Building > Groote Schuur Hospital > Observatory 7925 > Cape Town South Africa > Tel : +27 021 4047719 > Fax: +27 021 4481989 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology& Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected] http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford