Re: allometric scaling for renal elimination drug
Chao,
The answer to your simple question is "yes".
This paper describes the use of allometric scaling for GFR -- the prototype for all renal elimination processes.
Rhodin MM, Anderson BJ, Peters AM, Coulthard MG, Wilkins B, Cole M, et al. Human renal function maturation: a quantitative description using weight and postmenstrual age. Pediatr Nephrol. 2009;24(1):67-76.
Best wishes,
Nick
Quoted reply history
On 4/08/2011 2:46 a.m., CHAO ZHANG wrote:
> Dear NMuser,
>
> I have a question about allometric scaling. Can allometric scaling be used to a renal elimination drug?
>
> Thanks.
> Chao Zhang
> Division of Clinical Pharmacology
> Department of Medicine
> University of Cape Town
> K45, Old Main Building
> Groote Schuur Hospital
> Observatory 7925
> Cape Town South Africa
> Tel : +27 021 4047719
> Fax: +27 021 4481989
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology& Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
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