Hello NONMEM Users,
NONMEM outputs for few subjects look strange. Some subjects have 2 Cmax
(IPRED) after a single SC dose. One Cmax looks normal. Another one is a
smaller bump before the normal Cmax. Otherwise, the problem runs OK. Can it
be an integration error? I use ADVAN13.
Thank you,
Pavel
2 cmax after a single SC dose
Is this a simulation run? May be residual error? I never seen integration
problem to result in incorrect profiles. Also check the data file, may be extra
dose was given?
Leonid
Quoted reply history
> On Nov 2, 2013, at 8:01 PM, [email protected] wrote:
>
> Hello NONMEM Users,
>
> NONMEM outputs for few subjects look strange. Some subjects have 2 Cmax
> (IPRED) after a single SC dose. One Cmax looks normal. Another one is a
> smaller bump before the normal Cmax. Otherwise, the problem runs OK. Can it
> be an integration error? I use ADVAN13.
>
> Thank you,
> Pavel
Hi Pavel,
Since you say that IPRED shows two Cmax this could not be residual error.
Like Leonid I would believe this is rather an error in setup (control stream or
dataset) rather than an error with nonmem.
However, since you are using an ADVAN13 model, I suppose if the dose is split
into absorption into two compartments; if you have zero order absorption into a
deep compartment you may see this kind of behaviour. Since you only see
duplicate Cmax in some subjects, I would suggest you look at these subjects to
find out how they are different. Is it dose/formulation, the observation time
points, or eta values that are different from the other subjects?
Best
Jakob
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Leonid Gibiansky
Sent: 03 November 2013 02:49
Cc: nmusers
Subject: Re: [NMusers] 2 cmax after a single SC dose
Is this a simulation run? May be residual error? I never seen integration
problem to result in incorrect profiles. Also check the data file, may be extra
dose was given?
Leonid
> On Nov 2, 2013, at 8:01 PM, [email protected] wrote:
>
> Hello NONMEM Users,
>
> NONMEM outputs for few subjects look strange. Some subjects have 2 Cmax
> (IPRED) after a single SC dose. One Cmax looks normal. Another one is a
> smaller bump before the normal Cmax. Otherwise, the problem runs OK. Can it
> be an integration error? I use ADVAN13.
>
> Thank you,
> Pavel