Problem with initial values of the omega matrix with nonmem 7.6

From: Sebastiaan Sassen Date: March 18, 2026 technical Source: mail-archive.com
Dear colleagues, I ran into a problem with the omega matrix in nonmem 7.6 for a model I received (simple FOCE+I advan3 trans4 nothing special). In the model file it is specified like this (I tried different notations as simple decimals, scientific notation etc. to no avail): $OMEGA BLOCK(3)   0.107               ; CL   0.48E-1 0.11          ; V1   0.42E-1 0.56E-1 0.084  ; V2 However, with nonmem 7.6 I get a problem with the initial estimates of omega. If I look at the list file I see that it is due to my omega block, which makes sense as the correlations between these values used as initial values of etas are not valid (outside of -1,1). However, these initial estimates are not the ones I provided. Compare this to the same exact model ran on nonmem 7.4.4. Here the initial omega estimates are as described in the model and it runs well. Even in a clean folder without any files other than the dataset (csv) and the model file (mod). Am I doing something wrong or is this something else? Nonmem 7.6: INITIAL ESTIMATE OF OMEGA HAS A NONZERO BLOCK WHICH IS NUMERICALLY NOT POSITIVE DEFINITE 0INITIAL ESTIMATE OF OMEGA: BLOCK SET NO. BLOCK FIXED 1 NO 0.1000E+01 0.4000E+01 0.1000E+01 0.4000E+01 0.5000E+01 0.8000E+01 Compared to nonmem 7.4.4, which seems to do this correctly:      0INITIAL ESTIMATE OF OMEGA: BLOCK SET NO. BLOCK FIXED 1 NO 0.1070E+00 0.4800E-01 0.1100E+00 0.4200E-01 0.5600E-01 0.8400E-01 Best regards, Sebastiaan
Mar 18, 2026 Sebastiaan Sassen Problem with initial values of the omega matrix with nonmem 7.6
Mar 18, 2026 Philip Harder Delff Re: Problem with initial values of the omega matrix with nonmem 7.6
Mar 18, 2026 Sébastien Bihorel Re: Problem with initial values of the omega matrix with nonmem 7.6
Mar 20, 2026 Sebastiaan Sassen Re: Problem with initial values of the omega matrix with nonmem 7.6