Re: NONMEM and Bioavailability fraction
Hi Marie,
The message "PK PARAMETER FOR BIOAVAILABILITY FRACTION IS NEGATIVE" indicates
the source of your issue, but it can be misleading as NONMEM can also report
this error message if the bioavailability parameter is 0.
I would suggest that you look at the parameterization of your bioavailability
parameter (F1, F2, etc...) and check if the value can be set to 0 or negative
values (particularly if you have an IIV term on it)... Maybe share your full
model code if you are not sure how to fix the issue.
Sebastien
Regeneron - Internal
Regeneron - Internal
Quoted reply history
________________________________
From: [email protected] <[email protected]> on behalf of
Marie Rajerison <[email protected]>
Sent: Tuesday, March 11, 2025 9:39 AM
To: [email protected] <[email protected]>
Subject: [External] [NMusers] NONMEM and Bioavailability fraction
Dear NM users I am running an extravascular pop PK model with dual absorption
and got the following message from NM: Has anyone experienced the same issue
and how to fix it? Thank you in advance for your help Marie
Dear NM users
I am running an extravascular pop PK model with dual absorption and got the
following message from NM:
[cid:[email protected]]
Has anyone experienced the same issue and how to fix it?
Thank you in advance for your help
Marie
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