RE: Numerical instabilities in NM 7.5 ADVAN7, maybe related to gfortran 9.4.0?

Please read the nm751_bug_list.pdf document that is located in: https://nonmem.iconplc.com/nonmem751 In particular items 1 and 6 describe problems pertaining to ADVAN5 and ADVAN7. The work-around is to set the option -prdefault at the command line, or insert $SIZES PC=$SIZES PC=xxx where xxx>=2*NCOMPARTMENTS+1 In addition, this may resolve the speed difference you observed with ADVAN6. It is unlikely that gfortran 9.4 has the optimization switch problem (the -O3 switch in particular) encountered in gfortran 14. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 731 Arbor way, suite 100 Blue Bell, PA 19422 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com/