RE: [EXTERNAL] Re: Problems when implementing M3 for BLQs

From: [email protected] <[email protected]> On Behalf Of Leonid Gibiansky Sent: Wednesday, August 17, 2022 1:48 PM To: Roeland Wasmann <[email protected]>; [email protected] Subject: [EXTERNAL] Re: [NMusers] Problems when implementing M3 for BLQs Hi Roeland, ERROR_TERM in Y and in DUM should differ: one should include EPS() while the other should use only SD. F_FLAG should be set to zero outside M3 block. What is DRUG.EQ.1, is it parent? there should be a separate M3 part for metabolite. It would be easier to debug if you would provide the full code of the ERROR block Thank you, Leonid On 8/16/2022 6:53 AM, Roeland Wasmann wrote: > Hi all, > > I have a problem while trying to implement the m3 method in my model > with a parent and metabolite. I could really use some help. > > About 50% of the parent data is BLQ while the metabolite only has a > couple of BLQs. When modeling them separately there is no issue but when > I have them both in one model, I get the following error: > > /Recompiling certain components. > starting wait > ending wait > Exiting lpreddo > Compiling FSUBS > FSUBS.f90:1322:6:/ > > / B000056=PHI(DUM)/ > > / 1/ > > /Error: Unclassifiable statement at (1) > Building NONMEM Executable > gfortran: error: fsubs.o: No such file or directory > No nonmem execution. > It seems like Fortran compilation by NONMEM's nmfe script failed. Cannot > start NONMEM. > Go to the NM_run1 subdirectory and run psn.mod with NONMEM's nmfe script > to diagnose the problem./ > > The NM_run1 folder does not provide any answers… The M3 part of the > error block looks like this: > > Y = IPRED + ERROR_TERM > > *DUM = (LLOQ-IPRED) / ERROR_TERM > CUMD = PHI(DUM) > IF (ICALL.NE.4.AND.BLQ.GT.0.AND.DRUG.EQ.1) THEN > F_FLAG = 1 > Y = CUMD > MDVRES = 1 > ENDIF* > > When I put the “DUM” part within the PHI (i.e., “*CUMD = > PHI(((LLOQ-IPRED) / ERROR_TERM))*” the error changes slightly: > > /Compiling FSUBS > FSUBS.f90:1324:6:/ > > / B000058=PHI(B000056)/ > > When I remove the “*.AND.DRUG.EQ.1*” from IF I get: > > /FSUBS.f90:1355:6:/ > > / B000061=PHI(DUM)/ > > Please let me know what info I should provide to better diagnose this > problem challenge. > > Thanks in advance for helping out! > > Cheers Roeland > > ------------------------------------------ > > *Roeland Wasmann, PharmD, PhD* > > Division of Clinical Pharmacology > > Department of Medicine > > University of Cape Town > > K45 Old Main Building > > Groote Schuur Hospital > > Observatory, Cape Town > > 7925 South Africa > > phone: +27 21 650 4861 > > Disclaimer - University of Cape Town This email is subject to UCT > policies and email disclaimer published on our website at > http://www.uct.ac.za/main/email-disclaimer > or obtainable from +27 21 650 > 9111. If this email is not related to the business of UCT, it is sent by > the sender in an individual capacity. Please report security incidents > or abuse via > https://csirt.uct.ac.za/page/report-an-incident.php.