Re: SEED status with SAEM method
Dear Le Ba,
The most optimal way would be to tune other SAEM settings to see whether the results become more insensitive to the seed. Your use of a lower NBURN might be because you do not reach convergence. If that is indeed the case, that would also an objective to reach by improving settings. There are many settings to tune, please refer to the nonmem guide (nm7XX.pdf) for a list of options.
Hope this helps,
Jeroen
http://pd-value.com
[email protected]
@PD_value
+31 6 23118438
-- More value out of your data!
Quoted reply history
On 5/11/20 9:41 am, hai le ba wrote:
> Hello nmusers,
>
> I've tried to test the SAEM method on my dataset (1 sample for each ID) with different SEED status. Sometimes, I've got good results (with RSE <50%), but sometimes I can't get it.
>
> Example:
>
> $EST METHOD=SAEM INTERACTION NBURN=3000 NITER=500 AUTO=1 PRINT=100 SEED=123456789
>
> $EST METHOD=IMP EONLY=1 PRINT=1 NITER=5 ISAMPLE=1000 MAPITER=0
> I've got EPS : 0.00064 (RSE=63%)
>
> but
>
> $EST METHOD=SAEM INTERACTION NBURN=3000 NITER=500 AUTO=1 PRINT=100 SEED=123235489
>
> $EST METHOD=IMP EONLY=1 PRINT=1 NITER=5 ISAMPLE=1000 MAPITER=0
> I've got EPS : 0.0223 (RSE=18%)
>
> Could i trust on the good results (EPS=0.0223)? How can we control this problem?
>
> Thank you very much,
> Hai, LE Ba
> Ph.D Student
> La faculté de Pharmacie - Aix Marseille université
> Hanoi university of Pharmacy
> Email: [email protected] <mailto:[email protected]>
>
> [email protected] < mailto: [email protected] >; [email protected] < mailto: [email protected] >