Re: cumulative AUC
Hi Sam,
You can activate a flag from 0 to 1 from a certain timepoint (eg FLA1) and
integrate the auc as follows
Datdt(x)=C*FLA1
Rob
Op 8 nov. 2019 om 19:16 heeft Sam Liao <[email protected]> het volgende
geschreven:
Dear nmusers,
I have a question how to reset cumulative AUC in a $DES model, where DADT(4) is
set up as cumulative AUC of C1.
Because the study is a four way crossover study, the cumulative value of A(4)
need to rest to zero before each subsequent treatments.
However, NONMEM do not allow setting A(4) to zero in the statement of control
stream.
Is there any work around of this problem?
Best regards,
Sam Liao
Quoted reply history
On 11/7/2019 7:17 AM, Farrell, Colm wrote:
At ICON, it’s our people that set us apart.
As a global provider of drug development solutions, our work is serious
business. But that doesn’t mean you can’t have fun while you do it. With our
vision to be the partner of choice in drug development, we hire only the best
and brightest in the industry. Are you one of them?
Due to the continuing demand to support our clients in drug development through
the integration of modelling and simulation into clinical development programs,
ICON is looking for an experienced pharmacometrician to join our global PKPDM&S
team, with a key responsibility to develop and apply M&S strategies, study
designs and analyses across all phases of drug development. With members of
the PKPDM&S based in UK and USA, we’re flexible on the location.
The role
· Prepare PKPDM&S-based strategies to support clinical development
programs;
· Design, conduct, interpret and prepare appropriate study and
regulatory summaries of PKPDM&S activities;
· Build and sustain great relationships with clients;
· Prepare and present scientific publications;
· Serve as scientific reviewer and staff mentor to colleagues.
What you need
· PhD (or equivalent experience) in pharmacokinetics/PKPD with proven
industry or academic post PhD experience;
· Excellent understanding of the integration of PKPDM&S into clinical
drug development
· Demonstrated expertise in hands-on population-based modelling e.g.
NONMEM, Monolix and related software (R, Xpose, PsN);
· Proven mentorship capabilities.
Why join us
ICON enjoys a strong reputation for quality and is focused on staff
development. We make it our mission to attract the most diverse and creative
minds into the business and we continually strive to provide opportunities for
our people to excel, grow and build a phenomenal career. We understand that our
greatest asset is the skills and talents of our people and they are truly what
set us apart. Other than working with a great team of switched on and ambitious
people, we also offer a very competitive benefits package. This varies from
country to country so a dedicated recruiter will discuss this with you at
interview stage. We care about our people as they are the key to our success.
We provide an open and friendly work environment where we empower people and
provide them with opportunities to develop their long term career. ICON is an
equal opportunity employer - M/F/D/V and committed to providing a workplace
free of any discrimination or harassment.
To find out more and apply for the role, please visit:
https://icon.wd3.myworkdayjobs.com/broadbean_external/job/UK-London-Marlow/Senior-PK-Scientist-II_061382-1