RE: Using evid 0 before dosing

Van: [email protected] <[email protected]> Namens Bill Denney Verzonden: woensdag 6 november 2019 16:12 Aan: Carlos ST <[email protected]>; [email protected] Onderwerp: RE: [NMusers] Using evid 0 before dosing Hi Carlos, It is commonly used. For most datasets, there will be at least one observation that occurs before dosing to estimate the baseline value, and in almost every scenario, the modeling dataset should mirror the real world actions. So, there is no issue with it, and usually you will have an EVID=0 before the first dose. Thanks, Bill -----Original Message----- From: [email protected] <[email protected]> On Behalf Of Carlos ST Sent: Wednesday, November 6, 2019 10:03 AM To: [email protected] Subject: [NMusers] Using evid 0 before dosing Dear NMUsers, I would like advice in the best practice to use evid 0 before dosing, which is to say an observation just before a dosing (*to estimate the value in that compartment just before dosing event). Thank you, Carlos, De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629. The content of this message is intended solely for the addressee. No rights can be derived from this message or its attachments. If you are not the intended recipient, we kindly request you to delete the message and inform the sender. It is strictly prohibited to disclose, copy or distribute this email or the information inside it, without a written consent from the sender. Radboud university medical center is registered with the Dutch Chamber of Commerce trade register with number 41055629.