Re: $PRIOR with normal for OMEGA?
Hi Mark,
Not sure about this but how about estimating THETAS scaling fix OMEGAs (e.g. CL
= THETA(1)*EXP(THETA(2)*ETA(1)) ; $OMEGA 1 fix)? Then you can implement the
prior in the same way for random effect parameters as you do for fixed effect
parameters.
Ps. Probably not be compatible with MU-parameterization.
Best regards,
Martin Bergstrand, Ph.D.
Senior Consultant
Pharmetheus AB
+46(0)709 994 396
[email protected]
www.pharmetheus.com
+46(0)18 513 328
U-A Science Park, Dag Hammarskjölds v. 52b
752 37 Uppsala, Sweden
Skickat från min iPhone
11 nov. 2016 kl. 04:57 skrev Mark Sale <[email protected]>:
> Is it possible to use a normal prior for OMEGA? The default is inverse
> Wishart, but I'd be interested in using Normal (insuring that it is positive
> definite) Any ideas?
>
> thanks
>
>
>
>
> Mark Sale M.D.
> Vice President, Modeling and Simulation
> Nuventra Pharma Sciences, Inc.
> 2525 Meridian Parkway, Suite 280
> Durham, NC 27713
> Phone (919)-973-0383
> [email protected]
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