RE: Simultaneous pk model of 2 drugs
Hello Chris,
What is the point of modeling 2 drugs in one NONMEM
code? Do the drugs interact? For example, you can have 2 monoclonal
antibodies competing for or binding to the same target and/or concentration of
one drug changes elimination rate or some other parameters of the other
one. If they do not interact, you can
model them separately. In some cases,
even if they interact you can model them separately using dose of one drug as a
covariate for the other one.
Regards,
Pavel
Quoted reply history
On Fri, Sep 02, 2016 at 01:22 PM, Penland, Chris wrote:
Greetings NMusers,
Does nonmem have the capacity, unbeknownst to me, for modeling two simultaneous drugs?
I would like some suggestions about how to define the dataset and model for a subcutaneous drug and oral drug being administered on different schedules. I would use DVID = 1 and 2 for the two plasma pk observations. I figure this soft of thing had to be dealt with in the past when trying to model dynamic DDIs (vs, just taking one of the drugs as a covariate on the other’s parameters).
One approach is to specify the compartments for each to be dosed into then have those feed the central, but I’m curious to see if there is something more subtle in the nonmem syntax. Is there something about EVID, that I don’t know that
would help (beyond EVID=1 for dosing)
What if you had two oral drugs? Would you treat the two dosing compartments as separate and possibly link them together at the parameter/covariance level?
Thanks,
Chris
Chris Penland, PhD
ECD / Quantitative Clinical Pharmacology
Waltham, MA USA
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