Simultaneous pk model of 2 drugs

Greetings NMusers, Does nonmem have the capacity, unbeknownst to me, for modeling two simultaneous drugs? I would like some suggestions about how to define the dataset and model for a subcutaneous drug and oral drug being administered on different schedules. I would use DVID = 1 and 2 for the two plasma pk observations. I figure this soft of thing had to be dealt with in the past when trying to model dynamic DDIs (vs, just taking one of the drugs as a covariate on the other's parameters). One approach is to specify the compartments for each to be dosed into then have those feed the central, but I'm curious to see if there is something more subtle in the nonmem syntax. Is there something about EVID, that I don't know that would help (beyond EVID=1 for dosing) What if you had two oral drugs? Would you treat the two dosing compartments as separate and possibly link them together at the parameter/covariance level? Thanks, Chris Chris Penland, PhD ECD / Quantitative Clinical Pharmacology Waltham, MA USA ________________________________ Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.