model of error, linearisation, additive error, and VPC
Hello NONMEM Users,
When I tried to print log-scaled VPC, there was an error message about negative values. It can be caused by an additive error and/or linearization of the
error model when NONMEM transforms
Y = F*DEXP(ERR(1)*SD1) into Y =
F+ F*ERR(1)*SD1. The error is inflated at small concentrations and removing the additive term
is not an option in my case.
Is there an easy way to
solve it? It can be something like Y = F**GAMMA*DEXP(ERR(1)*SD1) or
Y = F+ F*ERR(1)*SD1 + F**GAMMA*ERR(2)*SD2, where GAMMA<1.
Thanks,
Pavel