model of error, linearisation, additive error, and VPC

From: Pavel Belo Date: January 29, 2016 technical Source: mail-archive.com
Hello NONMEM Users, When I tried to print log-scaled VPC, there was an error message about negative values. It can be caused by an additive error and/or linearization of the error model when NONMEM transforms Y = F*DEXP(ERR(1)*SD1) into Y = F+ F*ERR(1)*SD1. The error is inflated at small concentrations and removing the additive term is not an option in my case. Is there an easy way to solve it? It can be something like Y = F**GAMMA*DEXP(ERR(1)*SD1) or Y = F+ F*ERR(1)*SD1 + F**GAMMA*ERR(2)*SD2, where GAMMA<1. Thanks, Pavel
Jan 29, 2016 Pavel Belo model of error, linearisation, additive error, and VPC
Jan 31, 2016 Huub Jan Kleijn RE: model of error, linearisation, additive error, and VPC