Re: eigenvalues
Dear Pavel,
Are you using MATRIX=R when using NONMEM or the default sandwich estimator for
the covariance matrix? Most nonlinear regression packages use the equivalent
of MATRIX=R in NONMEM. You might try MATRIX=R on the $COV step and then
compare to Monolix.
Ken
Sent from my iPhone
Quoted reply history
> On Nov 6, 2015, at 8:42 AM, Pavel Belo <[email protected]> wrote:
>
> unstable in the middle with or without simulated annealing.
>
> I do not take sides. I just try to understand it. As max/min is frequently
> reported in BLAs, it is nice to understand what we report