Re: popPDx- error in running the model data set

On Wed, Oct 21, 2015 at 5:14 PM, Bharadwaj, Manushree < [email protected]> wrote: > *Dear friends*, > > *I am exploring the popPDx. In the library I found few data sets. I picked > data1.csv from the library and it looks like below. The ID are from 1 to 6 > and each have 25 observations. Looking at the data I can tell that it is a > single dose study and 25 samples are collected from each ID. * > C ID TIME DV AMT RATE 1 0 0 100 0 1 1 11.34 0 0 1 2 3.05 0 0 > *Under the model/run tab, there are many control streams available and the > one I selected is below (adv10tr1.ctl). The only changes I made in the > control stream are highlighted green. * > > ;Model Desc: One Comp. Michaelis-Menten Model - param: (VM/KM/V) > ;Project Name: LIBRARY > ;Project ID: GM00-005 > > $PROB RUN# adv10tr1 TrialA > $INPUT C ID TIME DV AMT DROP=RATE EVID ;etc. > $DATA data1.csv IGNORE=C > $SUBROUTINE ADVAN10 TRANS1 TOL=5 > $PK > ;TO NUMBER RECORDS WITHIN AN INDIVIDUAL > IF(NEWIND.LT.2) INDR=1 > IF(NEWIND.EQ.2) INDR=INDR+1 > IF(TIME.EQ.0) DOSE=AMT ;allows sorting graphs by dose > TVVM=THETA(1) > VM=TVVM*EXP(ETA(1)) > TVKM=THETA(2) > KM=TVKM*EXP(ETA(2)) > TVV=THETA(3) > V=TVV*EXP(ETA(3)) > S1=V > > $ERROR > IPRE=F > Y=F + F*ERR(1) +ERR(2) > CN=F/DOSE > $THETA > (0,10) ;[VM] > (0,10) ;[KM] > (0,1.0) ;[V] > $OMEGA > 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN VM > 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN KM > 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN V > $SIGMA > 0.1 ;[P] PROPORTIONAL COMPONENT OF RESIDUAL VARIABILITY > 0.001 ;[A] ADDITIVE COMPONENT OF RESIDUAL VARIABILITY > ;$MSF > $ESTIMATION MAXEVAL=9999 PRINT=5 POSTHOC MSF=adv10tr1.MSF > ;$SIMULATION ONLYSIM (9283745) > ;$COV > $TABLE ID TIME DOSE IPRE CN INDR FILE=adv10tr1.tab NOPRINT > $TABLE ID VM KM V ONEHEADER FILE=patabadv10tr1 NOPRINT > ;$TABLE ID NOPRINT ONEHEADER FILE=cotab001 > ;$TABLE ID NOPRINT ONEHEADER FILE=catab001 > ;$TABLE ID TIME IPRE NOPRINT ONEHEADER FILE=sdtab001 > > *On running the model, I got this error message 20 times (I have deleted > some repetitive text (RECORD 1 to 20) from the error and represented the > continuation with dotted lines).* > > WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1 > > (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION. > > (DATA WARNING 2) RECORD 1, DATA ITEM 6, CONTENTS: > THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES > IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING > VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM. > > ..................................................................................................................................................... > > ..................................................................................................................................................... > > (DATA WARNING 2) RECORD 20, DATA ITEM 6, CONTENTS: > THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES > IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING > VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM.* > > * THE MAXIMUM NUMBER OF WARNINGS OF ONE OR MORE TYPES WAS REACHED. > IT IS POSSIBLE THAT SOME WARNING MESSAGES WERE SUPPRESSED. > > *Could someone please tell me what error is this? As per my knowledge, if > we ignore C and drop the data item RATE, which has already been specified > in the $INPUT statement, then there are only 4 data items left (ID TIME DV > and AMT). So, why did this error occur?* > *Moreover, what does it mean by "NULLS WERE SUPPLIED FOR MISSING* > * VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM"* > > *Thank you,* > *Manushree* > > -- > *With regards-* > *Manushree Bharadwaj, BVSc, PhD Candidate* > *Graduate Teaching Associate* > *Department of Physiological Sciences* > *Center for Veterinary Health Sciences* > *Oklahoma State University* > *Stillwater, OK-74074* > -- *With regards-* *Manushree Bharadwaj, BVSc, PhD Candidate* *Graduate Teaching Associate* *Department of Physiological Sciences* *Center for Veterinary Health Sciences* *Oklahoma State University* *Stillwater, OK-74074*