popPDx- error in running the model data set

*Dear friends*, *I am exploring the popPDx. In the library I found few data sets. I picked data1.csv from the library and it looks like below. The ID are from 1 to 6 and each have 25 observations. Looking at the data I can tell that it is a single dose study and 25 samples are collected from each ID. * C ID TIME DV AMT RATE 1 0 0 100 0 1 1 11.34 0 0 1 2 3.05 0 0 *Under the model/run tab, there are many control streams available and the one I selected is below (adv10tr1.ctl). The only changes I made in the control stream are highlighted green. * ;Model Desc: One Comp. Michaelis-Menten Model - param: (VM/KM/V) ;Project Name: LIBRARY ;Project ID: GM00-005 $PROB RUN# adv10tr1 TrialA $INPUT C ID TIME DV AMT DROP=RATE EVID ;etc. $DATA data1.csv IGNORE=C $SUBROUTINE ADVAN10 TRANS1 TOL=5 $PK ;TO NUMBER RECORDS WITHIN AN INDIVIDUAL IF(NEWIND.LT.2) INDR=1 IF(NEWIND.EQ.2) INDR=INDR+1 IF(TIME.EQ.0) DOSE=AMT ;allows sorting graphs by dose TVVM=THETA(1) VM=TVVM*EXP(ETA(1)) TVKM=THETA(2) KM=TVKM*EXP(ETA(2)) TVV=THETA(3) V=TVV*EXP(ETA(3)) S1=V $ERROR IPRE=F Y=F + F*ERR(1) +ERR(2) CN=F/DOSE $THETA (0,10) ;[VM] (0,10) ;[KM] (0,1.0) ;[V] $OMEGA 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN VM 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN KM 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN V $SIGMA 0.1 ;[P] PROPORTIONAL COMPONENT OF RESIDUAL VARIABILITY 0.001 ;[A] ADDITIVE COMPONENT OF RESIDUAL VARIABILITY ;$MSF $ESTIMATION MAXEVAL=9999 PRINT=5 POSTHOC MSF=adv10tr1.MSF ;$SIMULATION ONLYSIM (9283745) ;$COV $TABLE ID TIME DOSE IPRE CN INDR FILE=adv10tr1.tab NOPRINT $TABLE ID VM KM V ONEHEADER FILE=patabadv10tr1 NOPRINT ;$TABLE ID NOPRINT ONEHEADER FILE=cotab001 ;$TABLE ID NOPRINT ONEHEADER FILE=catab001 ;$TABLE ID TIME IPRE NOPRINT ONEHEADER FILE=sdtab001 *On running the model, I got this error message 20 times (I have deleted some repetitive text (RECORD 1 to 20) from the error and represented the continuation with dotted lines).* WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1 (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION. (DATA WARNING 2) RECORD 1, DATA ITEM 6, CONTENTS: THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM. ..................................................................................................................................................... ..................................................................................................................................................... (DATA WARNING 2) RECORD 20, DATA ITEM 6, CONTENTS: THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM.* * THE MAXIMUM NUMBER OF WARNINGS OF ONE OR MORE TYPES WAS REACHED. IT IS POSSIBLE THAT SOME WARNING MESSAGES WERE SUPPRESSED. *Could someone please tell me what error is this? As per my knowledge, if we ignore C and drop the data item RATE, which has already been specified in the $INPUT statement, then there are only 4 data items left (ID TIME DV and AMT). So, why did this error occur?* *Moreover, what does it mean by "NULLS WERE SUPPLIED FOR MISSING* * VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM"* *Thank you,* *Manushree* -- *With regards-* *Manushree Bharadwaj, BVSc, PhD Candidate* *Graduate Teaching Associate* *Department of Physiological Sciences* *Center for Veterinary Health Sciences* *Oklahoma State University* *Stillwater, OK-74074*