RE: No message
Hi Peggy,
You need to define your compartments properly. You shouldn’t have a
semi-colon before them. You may try this;
$MODEL NCOMP=2 NPAR=6
COMP=(CENTRAL, DEFOBS, DEFDOSE)
COMP=(PERIPH)
Sincerely,
Ahmad Abuhelwa, PhD Candidate
Australian Center for Pharmacometrics |P1-09| Playford Building
School of Pharmacy and Medical Sciences
University of South Australia- City East Campus
Adelaide, South Australia
Australia
Email:
[email protected]<mailto:[email protected]>
Mobile: +61 413118743
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Chiaying Lin
Sent: Tuesday, 25 August 2015 10:46 AM
To: [email protected]
Subject: [NMusers] No message
Dear NM-Users,
I'm a NONMEM beginner. The following are my control stream for a monoclonal
antibody which clears via target mediated disposition. However, when I ran
NONMEM, I didn't get minimization successful message (in fact, no message at
all), there are also no Table output and the xx.g77 file contains only empty
three output files. I will be appriciated if someone help to find mistakes.
Thanks.
Peggy
---------------------------------------------------------------------------------------------------------------------------------------
$PROBLEM **base model**
$DATA PKDATA.CSV IGNORE=C
$INPUT ID TIME AMT NDV=DROP LNDV=DV EVID MDV CMT BW AGE DOSE
$SUBROUTINE ADVAN6 TRANS1 TOL=3
$MODEL NCOMP=2 NPAR=6
;COMP=(CENTRAL DEFOBSERVATION DEFDOSE)
;COMP=(PERIPH)
$PK
TVVMAX=THETA(1)
VMAX=TVVMAX*EXP(ETA(1))
KM=THETA(2)
TVV1=THETA(3)
V1=TVV1*EXP(ETA(2))
TVV2=THETA(4)
V2=TVV2*EXP(ETA(3))
Q=THETA(5)*EXP(ETA(4))
S1=V1
$DES
C1=A(1)/V1
C2=A(2)/V2
DADT(1)=-VMAX*C1/(KM+C1)-(Q*C1)+(Q*C2)
DADT(2)=(Q*C1)-(Q*C2)
$ERROR
CALLFL=0
IPRED=LOG(F)
IRES=DV-IPRED
IWRES=IRES/IPRED
Y=IPRED+ERR(1)
$THETA
(0.1, 1.49, 5) ;VMAX (mg/hr)
(1, 50,300) ;KM (μg/mL)
(1.3, 2.72, 5) ;V1 (L)
(1.1, 2.43, 5) ;V2 (L)
(0.001, 0.095, 1) ;Q (L/hr)
$OMEGA .025 ;VMAX
$OMEGA .032 ;V1
$OMEGA .29 ;V2
$OMEGA .975 ;Q
$SIGMA
0.030 ;ERR(1)
$ESTIMATION METH=1 MAXEVAL=9999 PRINT=5 POSTHOC
$COVARIANCE
$TABLE ID TIME DV IPRED IWRES VMAX KM V1 V2 Q ETA1 ETA2 ETA3 ETA4 BW AGE
NOPRINT ONEHEADER FILE=1.fit
$TABLE ID TIME AMT IPRED IWRES NOPRINT ONEHEADER FILE=sdtab1
$TABLE ID VMAX KM V1 V2 Q ETA1 ETA2 ETA3 ETA4 NOPRINT ONEHEADER FILE=patab1
$TABLE ID BW AGE NOPRINT ONEHEADER FILE=cotab1
----------------------------------------------------------------------------------------------------------------------------------
#ID
TIME
AMT
NDV
LNDV
EVID
MDV
CMT
BW
AGE
DOSE
A-P001
0
81.3
.
.
1
1
1
81.3
50
81.3
A-P001
0.25
4.8
1.568616
1
81.3
50
81.3
A-P001
1
18
2.890372
1
81.3
50
81.3
LNDV=Ln-transformed con. (mcg/ml)