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Dear NM-Users, I'm a NONMEM beginner. The following are my control stream for a monoclonal antibody which clears via target mediated disposition. However, when I ran NONMEM, I didn't get minimization successful message (in fact, no message at all), there are also no Table output and the xx.g77 file contains only empty three output files. I will be appriciated if someone help to find mistakes. Thanks. Peggy --------------------------------------------------------------------------------------------------------------------------------------- $PROBLEM **base model** $DATA PKDATA.CSV IGNORE=C $INPUT ID TIME AMT NDV=DROP LNDV=DV EVID MDV CMT BW AGE DOSE $SUBROUTINE ADVAN6 TRANS1 TOL=3 $MODEL NCOMP=2 NPAR=6 ;COMP=(CENTRAL DEFOBSERVATION DEFDOSE) ;COMP=(PERIPH) $PK TVVMAX=THETA(1) VMAX=TVVMAX*EXP(ETA(1)) KM=THETA(2) TVV1=THETA(3) V1=TVV1*EXP(ETA(2)) TVV2=THETA(4) V2=TVV2*EXP(ETA(3)) Q=THETA(5)*EXP(ETA(4)) S1=V1 $DES C1=A(1)/V1 C2=A(2)/V2 DADT(1)=-VMAX*C1/(KM+C1)-(Q*C1)+(Q*C2) DADT(2)=(Q*C1)-(Q*C2) $ERROR CALLFL=0 IPRED=LOG(F) IRES=DV-IPRED IWRES=IRES/IPRED Y=IPRED+ERR(1) $THETA (0.1, 1.49, 5) ;VMAX (mg/hr) (1, 50,300) ;KM (μg/mL) (1.3, 2.72, 5) ;V1 (L) (1.1, 2.43, 5) ;V2 (L) (0.001, 0.095, 1) ;Q (L/hr) $OMEGA .025 ;VMAX $OMEGA .032 ;V1 $OMEGA .29 ;V2 $OMEGA .975 ;Q $SIGMA 0.030 ;ERR(1) $ESTIMATION METH=1 MAXEVAL=9999 PRINT=5 POSTHOC $COVARIANCE $TABLE ID TIME DV IPRED IWRES VMAX KM V1 V2 Q ETA1 ETA2 ETA3 ETA4 BW AGE NOPRINT ONEHEADER FILE=1.fit $TABLE ID TIME AMT IPRED IWRES NOPRINT ONEHEADER FILE=sdtab1 $TABLE ID VMAX KM V1 V2 Q ETA1 ETA2 ETA3 ETA4 NOPRINT ONEHEADER FILE=patab1 $TABLE ID BW AGE NOPRINT ONEHEADER FILE=cotab1 ---------------------------------------------------------------------------------------------------------------------------------- #IDTIMEAMT NDV LNDV EVIDMDVCMTBWAGEDOSEA-P001081.3..11181.35081.3A-P0010.254.81.568616181.350 81.3A-P0011182.890372181.350 81.3 LNDV=Ln-transformed con. (mcg/ml)