Slow PRED in tables?
Hello everyone,
I have a curious problem with slow PRED calculations in tables. The estimations
are reasonably fast, 471 seconds for 23 iterations. If there is no PRED in any
tables then NONMEM finishes a moment after the message about elapsed estimation
time. But if is PRED in a table then it takes an extremely long time to return,
I waited more than 10 hours before I broke off the run.
If convergence of the algorithm is reasonably fast I get the impression that
the differential equations are not problematic (it is $DES solved with ADVAN13
TOL=9). In fact if I restart the run with all $OMEGA to (0 FIXED) - to force
all ETAs to zero - and do a MAX=0 run then it is quite fast.
I would expect calculating PRED would be simply setting ETA=0 and solving the
differential equations just once. Am I missing anything in how PRED in a table
is calculated?
Has anyone seen this kind of thing before? Any advice or tips?
Warm regards,
Douglas Eleveld
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