Slow PRED in tables?

From: Doug J. Eleveld Date: January 28, 2014 technical Source: mail-archive.com
Hello everyone, I have a curious problem with slow PRED calculations in tables. The estimations are reasonably fast, 471 seconds for 23 iterations. If there is no PRED in any tables then NONMEM finishes a moment after the message about elapsed estimation time. But if is PRED in a table then it takes an extremely long time to return, I waited more than 10 hours before I broke off the run. If convergence of the algorithm is reasonably fast I get the impression that the differential equations are not problematic (it is $DES solved with ADVAN13 TOL=9). In fact if I restart the run with all $OMEGA to (0 FIXED) - to force all ETAs to zero - and do a MAX=0 run then it is quite fast. I would expect calculating PRED would be simply setting ETA=0 and solving the differential equations just once. Am I missing anything in how PRED in a table is calculated? Has anyone seen this kind of thing before? Any advice or tips? Warm regards, Douglas Eleveld ________________________________
Jan 28, 2014 Doug J. Eleveld Slow PRED in tables?
Jan 29, 2014 Robert Bauer RE: Slow PRED in tables?
Jan 30, 2014 Bob Leary RE: Slow PRED in tables?
Jan 30, 2014 Doug J. Eleveld RE: Slow PRED in tables?
Jan 30, 2014 Robert Bauer RE: Slow PRED in tables?
Feb 03, 2014 Jerry Nedelman RE: Slow PRED in tables?
Feb 03, 2014 Bob Leary RE: Slow PRED in tables?
Feb 04, 2014 Alison Boeckmann Re: RE: Slow PRED in tables?