RE: Behavioural/Result differences for NONMEM version 5.

From: Erik Olofsen Date: August 06, 2013 news Source: mail-archive.com
Hi Chris, It could be that the SLOW option of the $EST step may be of use here (see the notes in nmhelp) - did you try that / does that help? Erik
Quoted reply history
________________________________ From: [email protected] [[email protected]] on behalf of Chris Franklin [[email protected]] Sent: Monday, August 05, 2013 5:15 PM To: [email protected] Subject: [NMusers] Behavioural/Result differences for NONMEM version 5. Hi, I know we all predominantly use NONMEM versions after NONMEM version 5. But we retain old versions to reproduce or work on historic activities. Anyway the question/issue: We are upgrading our infrastructure from RedHat 4 to RedHat 5 and Intel compiler from 10 to 12. We now have models that worked historically but we get anomalous behaviour varying from differences in theta and eta estimates in the 3rd significant digit up to runs that hang during the convergence steps. Has anyone else experienced these? Note: we have been informed of two compiler warnings during the installation phase: ifort: command line remark #10010: option '-Vaxlib' is deprecated and will be removed in a future release. See '-help deprecated' ifort: command line remark #10279: option '-xW' is deprecated and will be removed in a future release. See '-help deprecated' Your feedback/advice on this is most welcome. Regards, Chris Franklin ________________________________ This e-mail was sent by GlaxoSmithKline Services Unlimited (registered in England and Wales No. 1047315), which is a member of the GlaxoSmithKline group of companies. The registered address of GlaxoSmithKline Services Unlimited is 980 Great West Road, Brentford, Middlesex TW8 9GS.
Aug 05, 2013 Chris Franklin Behavioural/Result differences for NONMEM version 5.
Aug 06, 2013 Erik Olofsen RE: Behavioural/Result differences for NONMEM version 5.
Aug 14, 2013 Rik Schoemaker RE: Behavioural/Result differences for NONMEM version 5.