Behavioural/Result differences for NONMEM version 5.

Hi, I know we all predominantly use NONMEM versions after NONMEM version 5. But we retain old versions to reproduce or work on historic activities. Anyway the question/issue: We are upgrading our infrastructure from RedHat 4 to RedHat 5 and Intel compiler from 10 to 12. We now have models that worked historically but we get anomalous behaviour varying from differences in theta and eta estimates in the 3rd significant digit up to runs that hang during the convergence steps. Has anyone else experienced these? Note: we have been informed of two compiler warnings during the installation phase: ifort: command line remark #10010: option '-Vaxlib' is deprecated and will be removed in a future release. See '-help deprecated' ifort: command line remark #10279: option '-xW' is deprecated and will be removed in a future release. See '-help deprecated' Your feedback/advice on this is most welcome. Regards, Chris Franklin ________________________________ This e-mail was sent by GlaxoSmithKline Services Unlimited (registered in England and Wales No. 1047315), which is a member of the GlaxoSmithKline group of companies. The registered address of GlaxoSmithKline Services Unlimited is 980 Great West Road, Brentford, Middlesex TW8 9GS.