Reducing ETAs actually decreased OFV

From: Xinting Wang Date: August 11, 2013 technical Source: mail-archive.com
Dear all, Does anyone witnessed such a phenomenon in NONMEM as when you reduced an ETA, the OFV value, rather than increase, actually decreased? It's quite against intuition, as individual estimation should be better than population estimation in that particular parameter. Both models, whether having this ETA, converged very well. Best -- Xinting
Aug 11, 2013 Xinting Wang Reducing ETAs actually decreased OFV
Aug 11, 2013 Doug J. Eleveld RE: Reducing ETAs actually decreased OFV
Aug 12, 2013 Leonid Gibiansky Re: Reducing ETAs actually decreased OFV
Aug 12, 2013 Bill Denney Re: Reducing ETAs actually decreased OFV
Aug 25, 2013 Xinting Wang Re: Reducing ETAs actually decreased OFV
Aug 25, 2013 Bill Denney Re: Reducing ETAs actually decreased OFV
Aug 25, 2013 Leonid Gibiansky Re: Reducing ETAs actually decreased OFV
Aug 26, 2013 Xinting Wang Re: Reducing ETAs actually decreased OFV
Aug 26, 2013 Bill Denney RE: Reducing ETAs actually decreased OFV
Aug 26, 2013 Leonid Gibiansky Re: Reducing ETAs actually decreased OFV