Re: efavirenz pbpk input parameters
Hi Bernard
Please see the following two papers and if you search Pubmed you may find
more.
Rekic D, Roshammar D, Mukonzo J, and Ashton M (2011) In silico prediction
of efavirenz and rifampicin drug-drug interaction considering weight and
CYP2B6 phenotype. *Br J Clin Pharmacol* *71:*536-543.
Siccardi M, Marzolini C, Seden K, Almond L, Kirov A, Khoo S, Owen A, and
Back D (2013) Prediction of drug-drug Interactions Between Various
Antidepressants and Efavirenz or Boosted Protease Inhibitors Using a
Physiologically Based Pharmacokinetic Modelling Approach. *Clin
Pharmacokinet* *52:*583-592.
Regards
Masoud
Quoted reply history
On 1 July 2013 14:52, Bernard Ngara <[email protected]> wrote:
> Dear user
>
> I am learning modelling and simulation of the efavirenz compound using
> the In Silico PBPK approach. May you please assist with information on
> literature where i can obtain input a variety of model input
> parameters.
>
> Thank you
>
> Bernard
>
> BernardNgara
> Trainee Biostatistician
> Africa Institute of Biomedical Science and Technology
> P. O Box 2294
> Harare
> Zimbabwe
> +263 772 160 896
>