rounding issues with PK data

Dear nmusers, I have PK data from a compound with a very long half-life (weeks). I have two issues with this data and would very much like to hear your opinion on this: · Concentrations were rounded to integers, with LLOQ of 1. This means a concentration value of 2 could span values from 1.5-2.49, and unfortunately there is no way to find out what was originally measured, and I have quite a few measurements around LLOQ. How would you handle this in the coding (also later when mixing with additional data that was not rounded), and how will this rounding influence my parameter estimates? · The sampling times were only documented as dates (except for the day of dosing). With a long half-life compound, do you consider this to be critical? Your opinions would be very welcome. Best regards Nele ______________________________________________________________ Dr. Nele Käßner Principal Scientist Modeling and Simulation Global Pharmacometrics Experimental Medicine Takeda Pharmaceuticals International GmbH Thurgauerstrasse 130 8152 Glattpark-Opfikon (Zürich) Switzerland Visitor address: Alpenstrasse 3 8152 Glattpark-Opfikon (Zürich) Switzerland Phone: (+41) 44 / 55 51 404 Mobile: (+41) 79 / 654 33 99 mailto: [email protected]<mailto:[email protected]> http://www.takeda.com -------------------------------------------------------------------- The content of this email and of any files transmitted may contain confidential, proprietary or legally privileged information and is intended solely for the use of the person/s or entity/ies to whom it is addressed. If you have received this email in error you have no permission whatsoever to use, copy, disclose or forward all or any of its contents. Please immediately notify the sender and thereafter delete this email and any attachments.