RE: Single timepoint PKPD

Dear Bernard - I would suggest you start with the Users Guide provided with your nonmem installation. For a basic models there are excellent examples covering the theory, implementation and code examples for how to construct the control stream. For additional help there are a couple other resources that may provide useful (although the Users Guide is very thorough): * I would also suggest searching the NMusers archive - many problems have been solved over the years with snippets of code as well as solutions posted. * The accp pharmacometrics site has a couple case studies in the modeling section that include nonmem control streams. Be aware that they are slightly dated and refer to nonmem VI - though changes for your purposes would most likely be minor http://accp1.org/pharmacometrics/index.html * Some modeling environments such as Pirana offer 'template' control streams that you can use to start to get an idea of what is necessary. Finally, if you are looking for more in-depth explanations about both theory as well as examples including control streams, Metrum Institute offers well-designed online independent study courses in population PKPD modeling. Courses are split into lecture and live demo (lab sessions) in which you can pick up a lot in 'proper' methodologies behind both constructing and troubleshooting your model. If you have little experience in modeling I would highly recommend the Essentials of Population PK-PD modeling and Simulation found here: http://training.metruminstitute.org/course/category.php?id=11 Best of luck, Devin Pastoor Clinical Research Specialist University of Maryland, Baltimore Center for Translational Medicine