Re: single-patient AUC
Hi Markus,
Typically, AUCs are calculated using software like WinNonlin because it is both
simpler and more objective (the model is simple and specified a priori).
Generally, the model is just used as the linear-up, log-down trapezoidal rule
with personal (or corporate) preferences on handling BLQ and extrapolation to
infinity.
Thanks,
Bill
Quoted reply history
On Sep 1, 2012, at 11:13 PM, "markus joerger"
<[email protected]<mailto:[email protected]>> wrote:
dear NM-community,
Is NONMEM reliably used for single-patient AUC-calculation in cases of linear
PK, or is e.g. WinNonLin (or similar software) preferred in such cases?
best regards,
Markus
--
Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital
9007 St. Gallen
Switzerland
[email protected]<mailto:[email protected]>
[email protected]<mailto:[email protected]>
Phone: +41-765591070
Fax: +41-714946325