RE: WT as significant covariate on peripheral volume
Dear Ayyappa,What about the physicochemical properties of the drug ? Is the
drug lipophilic ?If yes, couldn't this mean that "higher body weight =
increased fat = increased volume in which the drug distributes or dissolves"
?Kind Regards,Ahmed Abbas SuleimanDepartment of Pharmacology - Clinical
Pharmacology UnitHospital of the University of Cologne (AöR)Gleueler Strasse
24, 50931 Köln, GermanyPhD Candidate at Bonn University, Germany
Quoted reply history
From: [email protected]
To: [email protected]
Date: Sat, 11 Aug 2012 19:20:46 -0400
Subject: [NMusers] WT as significant covariate on peripheral volume
Dear users, I am finding weight as a covariate on peripheral volume and
objective function is dropping more than on central volume in a two
compartment model. I am not sure if this is meaningful, I appreciate your
comments. Regards,Ayyappa