RE: Diagnostics
Dear Dr. N.FAA,
You supply insufficient information about your problem. In order to get useful
answers I suggest that you first answer the following questions.
1. What is the nature of your study/experiment?
2. In what way is the estimated KM value unrealistic?
3. You state that you are “not able to get the diagnostics plots”. Do you
mean that mean that no table files are generated? If so, what error messages
are returned by NONMEM?
Kind regards,
Martin Bergstrand, PhD
Pharmacometrics Research Group
Dept of Pharmaceutical Biosciences
Uppsala University, Sweden
Postal address: Box 591, 751 24 Uppsala, Sweden
Phone +46 709 994 396
Fax + 46 18 4714003
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of fakrudeen ali ahamed
Sent: den 1 augusti 2012 16:22
To: [email protected]
Subject: [NMusers] Diagnostics
Dear All,
I am trying to develop a pop pk model for my data.
my compound follows MM kinetics.
Pls find my control stream below.
$PROBLEM Pop pk modeling
;UNITS: TIME=h (h),CONCENTRATION=MG/L
;Vmax= µg/h, KM = µg/mL, VOLUME = L
;DOSE = MG
$DATA Pheny.csv IGNORE=#
$INPUT ID TIME DV MDV DVID AMT WT AGE SEX LFT
$SUBROUTINE ADVAN6 TRANS1 TOL=9
$MODEL
COMP=CENTRAL
$PK
Vmax=THETA(1)*EXP(ETA(1)) ;MAXIMUM RATE OF ELIMINATION
KM = THETA(2)*EXP(ETA(2)) ;CONC AT 50% Vmax
V =THETA(3)*EXP(ETA(3)) ;VOLUME OF DISTRIBUTION IN L
S1=V
$DES
CP=A(1)/S1
DADT(1)=-Vmax*CP/(KM+CP) ;UNITS OF VMAX = µg/h
$ERROR
Y=F+F*ERR(1)+ERR(2)
IPRED=F
$THETA (1,5) ;POPVMAX
$THETA (1,2) ;POPKM
$THETA (1,5) ;POPV
$OMEGA 0.04 ;BSVVMAX
$OMEGA 0.04 ;BSVKM
$OMEGA 0.09 ;BSVV
$SIGMA 0.02 ;ERRCV
$SIGMA 0.1 ;ERRSD
$ESTIMATION METHOD=1 INTERACTION MAXEVALS=9990 PRINT=5 POSTHOC
$COVARIANCE MATRIX=S
$TABLE ID AMT TIME DV MDV NOPRINT ONEHEADER FILE=mytab1
$TABLE ID TIME DV IPRED NOPRINT ONEHEADER FILE=sdtab1
$TABLE ID TIME DV NOPRINT ONEHEADER FILE=patab1
$TABLE ID AGE WT AMT NOPRINT ONEHEADER FILE=cotab1
$TABLE ID NOPRINT ONEHEADER FILE=catab1
The run was successful but am getting some unrealistic km value;also am not
able to get the diagnostics plots.
Any guidance or suggestions would be highly appreciated.
Regards
Dr.N.FAA
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