RE: Plasma and Urine data
Hi Norman,
I believe that you can use the standard ADVAN routines by putting the urine as
the excretion compartment (e.g. CMT = 3 for ADVAN3). What you would do is:
* Put an EVID=2 with CMT=3 at TIME 0 for each subject (to turn on the
output compartment),
* Put a row with EVID=0, CMT=3, and your observed AMOUNT (not
concentration) of drug in the urine at the end of its observation interval,
* After the EVID=0, CMT=3 row in the above bullet, you need to reset
the compartment to 0 concentration by turning it off then on:
EVID=2, CMT=-3 (note the negative to turn off)
EVID=2, CMT=3 (positive to turn on)
* Then use F3=THETA(X) to estimate the % renal excretion (relative to
F1 bioavailability); set V3=1.
The minimal, more concrete example of the data file is for subject 1 dosed at
time 0 with 5.5 mg measured in the urine at time 4 and 10 mg measured in the
urine at time 12:
ID TIME CMT EVID AMT
# Reset the subject
1 0 . 3 .
# Turn on the urine compartment
1 0 3 2 .
# Dose with 10 mg
1 0 1 1 10
# Any normal intermediate plasma concentration rows should go here.
1 1 2 0 2.2
# Amount in the urine at 4 hours
1 4 3 0 5.5
# Reset and restart the urine compartment
1 4 -3 2 .
1 4 3 2 .
Thanks,
Bill
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Norman Z
Sent: Wednesday, August 08, 2012 4:40 PM
To: [email protected]
Subject: [NMusers] Plasma and Urine data
Dear NMusers,
I am working on a dataset with drug concentration data in both plasma and
urine. I found most of the control streams dealing with urine data previously
posted here were based on user-defined differential equations. My question is
whether a normal ADVAN1 control stream and dataset can be changed to allow
urine data to be used. If so, what has to be change in the control stream and
the dataset? I'd sincerely appreciate it, if somebody can share with me a
sample control stream to simultaneously fit the plasma and urine data.
Kind regards,
Norman Zhou