Re: VD as a fraction of another VD

On 21/05/2012 8:19 p.m., Carlos Orlando Jacobo Cabral wrote: > Dear NMusers, > > Hi, I have data of a parent drug (intravenously administered) and its metabolite, ¿How can I code the volume of distribution of metabolite as a fraction of the central volume of parent? > > An example of the model that I want to fit is: > > $PK > > V1=THETA(1)*EXP(ETA(1)) ; Central Volume of parent > V2=THETA(2)*EXP(ETA(2)) ; Peripheral Volume of parent > Q=THETA(3) ; intercompartmental clearance > > V3= ???????????? ; Volume of metabolite as a fraction of V1 with variability > > CL1=THETA(5)*EXP(ETA(4)) ; Formation clearance of metabolite > CL2=THETA(6)*EXP(ETA(5)) ; Elimination clearance of metabolite > > CL0=THETA(7)*EXP(ETA(6)) ; Parent drug excretion by routes other than formation of metabolite > > - Thank you in advance. > > Orlando. > > /P//hD //student/ Carlos Orlando Jacobo Cabral > > Departamento de Farmacología, Lab.34 > > Centro de Investigación y de Estudios Avanzados del I. P. N. > > Email: [email protected] < mailto: [email protected] >; [email protected] < mailto: [email protected] > -- Nick Holford, Professor Clinical Pharmacology First World Conference on Pharmacometrics, 5-7 September 2012 Seoul, Korea http://www.go-wcop.org Dept Pharmacology& Clinical Pharmacology, Bldg 505 Room 202D University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected] http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford