Re: modeling of total concentration of two drugs with different kinetics in NONMEM

Dear Yaming I have two questions. 1.Were the drugs given at the same time as a fixed dose combination? 2. Do you have PK when the drugs are give separately? >>> Yaming Hang <[email protected]> 2012/04/25 03:22 PM >>> Dear All, I’m trying to model in NONMEM the kinetics of two drug entities co-existing in the blood. Since the assay cannot differentiate these two entities, I only have the total concentration of these two in the blood. Does anyone has similar experience? Can you please share the NONMEM code? Thanks, Yaming Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02142 Office: 781-464-1741 Fax: 617-679-3463 Email: [email protected] ### UNIVERSITY OF CAPE TOWN This e-mail is subject to the UCT ICT policies and e-mail disclaimer published on our website at http://www.uct.ac.za/about/policies/emaildisclaimer/ or obtainable from +27 21 650 9111. This e-mail is intended only for the person(s) to whom it is addressed. If the e-mail has reached you in error, please notify the author. If you are not the intended recipient of the e-mail you may not use, disclose, copy, redirect or print the content. If this e-mail is not related to the business of UCT it is sent by the sender in the sender's individual capacity. ###