Fourth and Last Announcement: 15th Fisher/Shafer NONMEM Workshop with PLT Tools

Dear Colleagues: You will be pleased to know that this is the last announcement for the 15th Fisher/Shafer NONMEM Workshop with PLT Tools. The course will be held in Bethesda, Maryland, from Wednesday, May 2nd, 2012 through Saturday, May 5th, 2012. The course description and registration details can be accessed at http://www.nonmemcourse.com/ www.nonmemcourse.com. This will be the last course that we hold in Bethesda for at least the next two years. I am returning to Stanford, so the courses for the next few years will be held in San Francisco. This is an intermediate-to-advanced course on the use of the NONMEM System, closely integrated with the PLT Tools graphical user interface for the NONMEM System. Although the focus of the workshop is NONMEM, the more advanced diagnostics (e.g., visual predictive check, log-likelihood profiling, bootstrap analysis, jackknife validation) and automation (e.g., automated covariate searching, analysis automation, and report automation) are presented in the context of PLT Tools. PLT Tools supports both NMFE and NMQUAL. Graphics can be produced from PLT Tools extensive graphics options, via automated linking to XPOSE graphics. Our NONMEM Workshops are now in their 8th year. We have spent the past five years developing PLT Tools. We introduced PLT Tools in 2009 and have introduced new features in each subsequent workshop. The feedback from these courses is that workshop participants learned advanced NONMEM analysis and diagnostic approaches quickly by using PLT Tools. PLT Tools can be freely downloaded at www.pltsoft.com. Participants are encouraged to consider two introductory workshops on Tuesday, May 1st (the day preceding the workshop): . Introduction to R: "Data Manipulation" (Tuesday morning) and "Statistics and Graphics" (Tuesday afternoon). R is a powerful statistical programming language. You do not need to know R to take the NONMEM Workshop, but R is an invaluable tool for preparing data files, performing statistical analysis, and preparing graphs. . Introduction to NONMEM (Tuesday afternoon): Participants who would like to brush up on NONMEM before starting the workshop on Wednesday are encouraged to attend this half-day session. Participants interested in additional training in PLT Tools can sign up for a half-day course devoted to PLT Tools we give on the afternoon of the last day (Saturday, November 12th). The Saturday workshop covers PLT Tools in greater detail, focusing on examples in which PLT Tools handles types of data analysis that are unwieldy if one attempts to work directly with NONMEM. Recent courses have sold out, so we encourage your registering early. Academic and government discounts are available (see http://www.nonmemcourse.com/ www.nonmemcourse.com). Please direct questions to <mailto:[email protected]> [email protected]. Dennis and I hope to see you in May 2012 in Bethesda! Sincerely, Steven L. Shafer, MD Professor of Anesthesiology, Columbia University Adjunct Professor of Anesthesia, Stanford University Adjunct Professor of Biopharmaceutical Sciences, UCSF Editor-in-Chief, Anesthesia & Analgesia