Re: Guidelines for a fresh modeller

I would also be interested in this. Thank-you. Brian Decker MD, PharmD Elisabet Størset <[email protected]> wrote: Dear NONMEMusers I am working with my very first pop-PK model with NONMEM and have no experience. I have read a lot of theory but lack experience of actually using nonmem. I see the OFV and estimates, but have trouble knowing how to interpret the results and the graphs, and how to improve the structural model before incorporate covariates. When I have nothing to compare with, it is difficult to know if I have found the right structural model and whether my results are actually good or bad. I also wonder what kind of plots in the plot jungle which you experience modelers find most useful to look at when trying to improve a model, and how you know which starting estimates to choose. Maybe any of you remember how it was to be a fresh modeller, and remember what you did to get your first experience. I could use a good, pedagogical, stepwise guide on modelling, with some illustrative examples and excercises to practice with before starting on my own dataset. Do any of you know if this is available? Thanks in advance :)