RE: analysis of non-positive DV
try an additive IIV and/or RV, depending on your MOA and measurement
error pattern.
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-----Original Message-----
From: [email protected] [mailto:[email protected]]
On Behalf Of Vinogradova Svetlana
Sent: Wednesday, September 21, 2011 8:26 AM
To: [email protected]
Subject: [NMusers] analysis of non-positive DV
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations
for each patient - vehicle (say baseline) and dose (treatment). We want
to analyze our dataset in terms of (treatment-baseline). So I've
modified my dataset, and now I have only one "column" of observations
for each patient: DV= (treatment-baseline). But now I have some problems
because I have some negitive values in DV column. In case of some models
it results in problems, for example:
TEFF = TBAS + (TSLP*CP)**TALP
so TSLP should be positive but it's not that right...
Maybe there are some common methods to deal with this case?
Thanks a lot,
Svetlana