RE: analysis of non-positive DV
You can do it that way, but you are throwing away data (the baseline
effect). Better to model baseline and effect. May prevent negative values
as well.
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Vinogradova Svetlana
Sent: Wednesday, September 21, 2011 8:26 AM
To: [email protected]
Subject: [NMusers] analysis of non-positive DV
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations for
each patient - vehicle (say baseline) and dose (treatment). We want to
analyze our dataset in terms of (treatment-baseline). So I've modified my
dataset, and now I have only one "column" of observations for each patient:
DV= (treatment-baseline). But now I have some problems because I have some
negitive values in DV column. In case of some models it results in problems,
for example:
TEFF = TBAS + (TSLP*CP)**TALP
so TSLP should be positive but it's not that right...
Maybe there are some common methods to deal with this case?
Thanks a lot,
Svetlana