RE: Modeling concentration data with imprecise sampling time
Dear Michael
I think you might want to use TSCALE (can also be written as XSCALE). This
PREDPP parameter lets you scale time, and you can also add an eta (should
you wish). The parameter is described in Guide VIII (Feb 2010). With
appropriate IF statements you should be able to scale the time around the 1
hr time point only.
Kind regards
Janet
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of [email protected]
Sent: 02 June 2011 17:45
To: [email protected]
Subject: [NMusers] Modeling concentration data with imprecise sampling time
All:
I have a data set following a constant rate 1-hour infusion where the
time of 1-hour sample is imprecise. In some cases the "1-hr" sample was
taken prior to infusion termination as it was intended; however, in others
it was quite apparently take after the infusion ended. I'm thinking of
modeling with the time of the "1-hr" sample as a "theta". Does anyone have
a NONMEM coding example showing how to do this? Any other suggestions as to
how to handle this would be appreciated as well.
Thanks,
Michael