Modeling concentration data with imprecise sampling time

From: Mdkzone Date: June 02, 2011 technical Source: mail-archive.com
All: I have a dataset following a constant rate 1-hour infusion where the time of 1-hour sampleis imprecise. In some cases the "1-hr" sample was taken prior to infusion termination as it was intended; however, in others it was quite apparently take after the infusion ended. I'm thinking of modeling with the time of the "1-hr" sample as a "theta". Does anyone have a NONMEM coding example showing how to do this? Any other suggestions as to how to handle this would be appreciated as well. Thanks, Michael
Jun 02, 2011 Mdkzone Modeling concentration data with imprecise sampling time
Jun 02, 2011 Matt Fidler RE: Modeling concentration data with imprecise sampling time
Jun 02, 2011 Leonid Gibiansky Re: Modeling concentration data with imprecise sampling time
Jun 02, 2011 Bill Denney RE: Modeling concentration data with imprecise sampling time
Jun 02, 2011 Mark Sale RE: Modeling concentration data with imprecise sampling time
Jun 03, 2011 Janet R. Wade RE: Modeling concentration data with imprecise sampling time
Jun 03, 2011 Leonid Gibiansky Re: Modeling concentration data with imprecise sampling time