Modeling concentration data with imprecise sampling time
All:
I have a dataset following a constant rate 1-hour infusion where the time of
1-hour sampleis imprecise. In some cases the "1-hr" sample was taken prior to
infusion termination as it was intended; however, in others it was quite
apparently take after the infusion ended. I'm thinking of modeling with the
time of the "1-hr" sample as a "theta". Does anyone have a NONMEM coding
example showing how to do this? Any other suggestions as to how to handle this
would be appreciated as well.
Thanks,
Michael