PAMAM-OH nanoparticles

Dears NMusers PAMAM Nanoparticles used as anticancer drug carrier. During a biodistribution study 5 mice were sacrificed at each sample time, 5, 30, 60, 120 minutes, and 6, and 24 hours, after a bolus infusion of 50mg/kg of PAMAM-OH. We are interested in the PAMAM-OH kinetics. Can we apply population pharmacokinetics analysis on these types of data? (i.e grouping the data as if they came from only 5 mice that were sampled at those times)? looking for ideas, suggestions