RE: Replacement of values during simulation
Dear Nathan and Nick:
Thank you very much for your help. Finally I'm exploring the model under this
conditions, and as Nathan explained before, I simulate the effect of an LOQ in
my resulting dataset. The final code is this:
LLOQ = LOG(0.020) ;LOW LIMIT OF QUANTIFICATION
Y=IPRED+W*EPS(1)
IF (ICALL.EQ.4)THEN ;Required to simulate IF (F.NE.0) Y=LOG(F)
IF(Y.LE.LLOQ) THEN;Required to replace values lower or equal than LOQ Y =
LLOQ ENDIFENDIF
This instruction allow me to work with PsN and "play around" to know my model.
I also try to use the code that Nick send me but it did not work. I wonder
where is the problem, just to close the circle...Elba.
Date: Sun, 24 Apr 2011 21:48:30 -0500
Subject: Re: [NMusers] Replacement of values during simulation
From: [email protected]
To: [email protected]
CC: [email protected]
Elba,
In the $ERROR block you can add code such as the following:
Y=F + F*ERR(1) + ERR(2)
; Replace values below -3.9 with -3.0
IF(Y.LE.-3.9) THEN
Y=-3.0
ENDIF
This can often be used to simulate the effect of an LOQ on the resulting
dataset.
Good luck!
Nathan
--
Nathan S. Teuscher, PhD
Founder, PK/PD Associates
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Quoted reply history
On Sat, Apr 23, 2011 at 11:53 AM, elba romero <[email protected]> wrote:
Dear nonmemusers:
I’m performing some simulations in order to verify the
behaviour of my model. My iDV and DV are time an concentration respectively.
In my case it would be useful to replace all simulated data
(DV) that have values less or equal than -3.9 by this value: -3.0.
Does anybody could help me how to give this instruction to
NONMEM7 in order to replace all this values during simulation?
Thank you in advance!
Elba
PhD student
UNAV