Re: basic questions...

On 31/03/2011 3:02 p.m., di Gion, Paola wrote: > Dear NONMEM users, > > as beginners in NONMEM we have the following questions: > > - What is the meaning of "DEL" and "W" (in the subroutine $ERROR)? They are sort of like a virus that is spread by copying and pasting from old control streams passed around among beginners. These are not standard NM-TRAN variables. Some people like to use them to create some diagnostic variables like IWRES. I find no use for them. > - What is the meaning of "TOL" and when should it be used? TOL is an option for the differential equation solving subroutines (ADVAN6, ADVAN8, ADVAN9 and ADVAN13 (NM7 only). It specifies the tolerance for the numerical solution of the differential equations. A reasonable starting value is TOL=6 for NM7 (with NSIG=2 and SIGL=6). > - Assumed we need to use $DES, is this possible only with NONMEM version 7 or can we use it also in NONMEM 6? You can use $DES with any version of NONMEM. It usually runs faster with NM6 than NM7. However, in some cases ADVAN13 in NONMEM7 will run faster than ADVAN6,8.9. Its hard to predict which ADVAN is best so just try different ones and use the one that runs fastest. > Thanks a lot and kind regards from rainy Cologne Its raining in Cape Town too! > Paola & Lisa -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology& Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected] http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford