Re: basic questions...

Paola & Lisa, Please see responses interspersed below. Best regards from snowy Buffalo, Luann Phillips Director PK/PD Cognigen Corporation (716) 633-3463 ext 236 di Gion, Paola wrote: > Dear NONMEM users, > > as beginners in NONMEM we have the following questions: > > - What is the meaning of "DEL" and "W" (in the subroutine $ERROR)? I don't think NONMEM has a standard definition for DEL and W. If you can send a copy of the code in which you saw these variables, I would be happy to explain them. > - What is the meaning of "TOL" and when should it be used? The TOL subroutine when either ADVAN 6, 8, 9, 10, or 13 is used. The following section of "NONMEM USERS GUIDE INTRODUCTION TO NONMEM 7" provides a very nice explanation of how NONMEM utilizes the value of TOL. Section I.14 Controlling the Precision of the Gradient Evaluation In classical NONMEM methods (First order, First order conditional A copy of this guide can be located at: ftp://nonmem.iconplc.com/Public/nonmem7/Release_Notes_Plus/ filename: intro712.pdf This explanation is helpful even if you're not using NONMEM 7. > - Assumed we need to use $DES, is this possible only with NONMEM version 7 or can we use it also in NONMEM 6? NONMEM6 and NONMEM7 have $DES. However, $DES is not always required. NONMEM supplies ADVANs to fit 1 and 2 CMT models and a few others without the use of $DES. Refer to the nmhelp for ADVAN and TRANS. Example: ADVAN1 --> A one compartment model Combined with TRANS1 --> PK parameter is K Combined with TRANS2 --> PK parameters are CL and V > Thanks a lot and kind regards from rainy Cologne > > Paola & Lisa