re: Drug PD interaction model
Dear Jorn,
The 2 drugs acting on the same receptor you can model using basic receptor
pharmacology. That interaction should be fairly predictable. The third
drug I would introduce using some semi-mechanistic model, dependent on how much
you know. Do you have a lot of data?
I would stay clear from anything that models "synergism".
Bart
Bart Laurijssens
BEL Pharm Consulting
Moulin d'Ozil, Chambonas 07140, France
Phone: +33 (0)685 16 55 94
[email protected]
> Message du 27/07/10 21:12
> De : "Jorn Lotsch"
> A : "[email protected]"
> Copie à :
> Objet : [NMusers] Drug PD interaction model
>
> Dear Nonmem users,
>
> I am looking for a model or a paper where it is reported that describes
> the interaction of three drugs, which act on the same PD parameter,
> however, two of them via independent mechanisms, whereas the third
> shares the mechanism of action, e.g., receptor, with one of the first
> two drugs. Any help, reference or direct modelling support, is
> appreciated and thanked for in advance.
>
> Best wishes
>
> Jorn Lotsch
>
> --
>
> _______________________________________________________
> Univ.-Prof. Dr. med. Jörn Lötsch
> pharmazentrum frankfurt/ZAFES
> Institut für Klinische Pharmakologie
> Goethe-Universität
> Theodor-Stern-Kai 7
> D-60590 Frankfurt am Main
>
> Tel.:069-6301-4589
> Fax.:069-6301-7636
> http://www.klinik.uni-frankfurt.de/zpharm/klin/
>
>
>
>
>
>