RE: Drug PD interaction model
Hello Jon,
I believe that there should be examples of this in the HIV literature. My
colleague, Joy Feng, published on this topic recently:
"The triple combination of tenofovir, emtricitabine and efavirenz shows
synergistic anti-HIV-1 activity in vitro: a mechanism of action study"
Feng, J.Y. et al. (2009) Retrovirology 6:44
This may not be exactly what you want as tenofovir and emtricitabine are both
nuc inhibitors of HIV reverse transcriptase, while efavirenz targets the same
enzyme but in a different manner. There may be similar papers out there, where
the third drug has a different target (e.g. HIV protease).
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Scientist, Drug Metabolism
Gilead Sciences, Foster City CA
Quoted reply history
________________________________
From: [email protected] [mailto:[email protected]] On
Behalf Of Jorn Lotsch
Sent: Tuesday, July 27, 2010 11:41 AM
To: [email protected]
Subject: [NMusers] Drug PD interaction model
Dear Nonmem users,
I am looking for a model or a paper where it is reported that describes the
interaction of three drugs, which act on the same PD parameter, however, two of
them via independent mechanisms, whereas the third shares the mechanism of
action, e.g., receptor, with one of the first two drugs. Any help, reference or
direct modelling support, is appreciated and thanked for in advance.
Best wishes
Jorn Lotsch
--
_______________________________________________________
Univ.-Prof. Dr. med. Jörn Lötsch
pharmazentrum frankfurt/ZAFES
Institut für Klinische Pharmakologie
Goethe-Universität
Theodor-Stern-Kai 7
D-60590 Frankfurt am Main
Tel.:069-6301-4589
Fax.:069-6301-7636
http://www.klinik.uni-frankfurt.de/zpharm/klin/