Meta-analysis with Nonmem

Dear NMUSERS, I wanted to investigate the dose-response relationship (Emax model) of a drug with NONMEM, based on data from literature (i.e. a meta-analysis). However, I am not quite sure how to deal with the different levels of random effects. Suppose I have 10 studies of different size where different doses were given and the response is presented as average change of a biomarker +/- standard deviation for each dose level. How would I incorporate the standard deviation of the biomarker measurements reported in each study for each dose level and how would I account for the different number of patients in the study? I would greatly appreciate your help, maybe with a NM-code snippet or reference to a paper where something similar has been done. Thanks in advance, Andreas. Andreas Lindauer Pharmacokineticist Pharmacokinetics and Metabolism R&D Center. Ferrer Internacional S.A. Juan de Sada 32, 08028 Barcelona [email protected] www.ferrergrupo.com ¿Necesita imprimir este mensaje? Protejamos el medio ambiente. Li cal imprimir aquest missatge? Protegim el medi ambient. Do you need to print this message? Let's protect the environment. Este mensaje, y en su caso, cualquier fichero anexo al mismo, puede contener información confidencial, siendo para uso exclusivo del destinatario, quedando prohibida su divulgación, copia o distribución a terceros sin la autorización expresa del remitente. Si Vd. ha recibido este mensaje erróneamente, se ruega lo notifique al remitente y proceda a su borrado. Gracias por su colaboración. This message and its annexed files may contain confidential information which is exclusively for the use of the addressee. It is strictly forbidden to distribute copies to third parties without the explicit permission of the sender. If you receive this message by mistake, please notify it to the sender and make sure to delete it. Thank you for your kind cooperation. <<image/gif>> <<image/gif>>